Every video summary and article, across all four pillars of longevity.
The pathway back isn't necessarily pain-free or injury-free. It's more of a trajectory that's going to get better.
If you walk in your corridor and there is a drop of blood there, you can tell what was the age of the person who lost that blood with a precision of plus or minus two years.
The brain is a hybrid car. So it's running on two fuels that are complementary.
It has been clearly shown that at the molecular level some of the effects of GLP-1s are independent of obesity.
Over 4 years of treatment, there was only 1 year of telomere shortening in the vitamin D randomized group, in comparison to the placebo group that had 4 years of telomere shortening.
If you have too many ways to measure something, that is a symptom that what you're measuring is not fundamental.
I tried it on myself, because nobody else was going to do anything. I didn't have a laboratory. I just had myself.
Knowledge is power in a case like that.
We have no tool that allows us to directly measure biological age.
About 70% of the immune system is in and around the gut.
Memory is really a mental representation of the past, and by its very nature it's reconstructive.
The problem with traditional blood work is that it's only useful for diagnosing bad problems. There's very little there predicting if you're going to head towards a chronic disease.
When I see a scan on a patient, it tells me your past in one scan. And if we have an opportunity to get a second scan, then I can tell you what your future looks like.
If someone were to change from a typical western diet to this optimal diet, say at the age of 20, you'd be looking at about a decade gained.
Are we really listening to the science, or are we only interested in purveying the preconceived narrative?
45%, nearly half of all dementia cases worldwide can be prevented with specific modifiable factors, not genetic destiny, not bad luck.
You got hurt while doing something active, but you were hurt because you were probably doing something your body wasn't quite prepared to do.
The sprint intervals plus the weight lifting is what's going to transform your body.
Cartilage is the end cap, like a bumper, of every bone.
The most important food element for brain function is fat.
This idea that if you live a healthy lifestyle, everything's going to be hunky-dory and nothing's ever going to go wrong — that's just not the way it works in the real world.
I feel like I'm in the field now almost as if I was an infectious disease doctor practicing before and after penicillin was discovered.
The cancer cells, by definition, are refusing these orders to protect.
They're sick very little time at the end of their life, usually weeks.
The biggest correlation seems to be with strength, which is a function of muscle mass.
If you are in the lower 25 percentile of VO2 max, you are twice as likely to be ill.
You want to kind of rack up the hours of low intensity physical activity and then intersperse it with this high-intensity exercise.
Creatine alone without resistance training does not build muscle.
When it comes to set two, three and four, that's where creatine really comes to the rescue.
To some degree, insulin resistance is a common root cause for most chronic diseases.
Sleep is not something that you do. Sleep is something that happens to you when the situation allows for it.
Women at age 52, their gas tank is empty. Perimenopause is this time where it's very erratic — the tank is over full and then it goes to empty really quickly without warning.
RNA tells you what is the function of a cell, not what is the potential.
You can build a great body on six exercises. Literally, the row, squat, deadlift, bench, pull-up, curl, done.
Recommended almost sounds like optimal — I think people confuse that with the optimal amount of protein.
Maybe it's not that we're over fat — it's that we're under muscled.
The research we have now really shows you can be a couple reps or three short of failure and still get roughly the same amount of muscle growth.
Sometimes it's like 1% science and then 99% hype — there's almost nothing to back it up in some of these cases.
For the same unit increase in ApoB you get a certain risk increase from LDL, but you get roughly a three or fourfold higher risk increase if you change remnant particle number by the same amount.
Do not get 9,000 biomarkers tested.
Did you know that we peak out on our bone density at 30?
Rapamycin is our best shot on goal if we want to pick a single drug to look at in the context of biological aging in humans.
The period length of the sleep rhythm on average is 24.2 hours.
If one's main goal is simply to lose weight, then it really does not matter what one eats, provided that the number of calories burned is higher than the number of calories ingested.
Protein restriction extends lifespan in laboratory mice, and FGF21 is required for this lifespan extension.
Every time that one engages in the compulsion related to the obsession, the obsession simply becomes stronger.
What we can see with our ancestors is that they are eating a range that is not just meat, but there's also plant foods, grasses, sedges.
The brain only has so many ways of saying ouch. And so when it's inflamed, you don't feel it.
It wasn't the science that was hard. It's what the science had to survive.
The rumination, the self-criticism, the inability to be present, these are not personality traits. They are a network malfunction.
It's the most effective longevity drug that we have today. It has been for the past 15 years.
Nothing associates more with mortality than age.
Every single one of us knows what we do. Some of us know how we do it, but very few of us can clearly articulate why we do what we do.
It's not what you're surrounded with — it's what you are connected to.
Her pull-up record right now is zero. So even if she just performs one pull-up as an 80-year-old woman, the record is hers.
This part of the brain called the hippocampus, that is really key to learning and memory, had an increase in volume just because they were having yogurt.
When a brand new car comes off the assembly line, you do a full diagnostic workup — and I think we should do the same thing with humans.
Diabetes is a symptom. High cholesterol is a symptom. Smoking is a habit.
If we didn't produce lactate, the muscles would not be able to function.
The red light therapy market is full of bold claims and easy answers, but the actual clinical literature is incredibly nuanced.
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