One in nine Americans over the age of 65 — that includes you and me — is already diagnosed with dementia. To not call that an epidemic is underselling it.
It becomes smooth and effortless to some extent. And that's the place where you want to get.
Psychiatry aims at reduction of symptoms but not restoration of the full human experience that makes life most worthwhile.
That idea of dogs living to be 30 is really a scientific moonshot. And I do think that it is realistic.
Could supermodels have more visceral fat than sumo wrestlers? Yes, they could.
Metabolic health is the core of everything.
540 million years ago, animals saw the first light.
Hope has become a product, and it's been attached to molecules that, quite frankly, haven't earned the claims made about them.
From the perspective of natural selection, we are here for one reason and one reason only: to take in food and make babies.
That's a self versus non-self discrimination problem, just like the immune system has to do.
The mitochondria can ramp up temperatures up to about 60°C, which would be almost a lethal temperature if that was your body temperature during a fever.
These things have some biological activity, but they don't move the needle the way diet, exercise, sleep, hormones, or GLPs do. They're incremental at best.
If we can solve aging itself, why don't we target that root cause, because it's causing 80% of all disease?
People have fears that these devices are going in and reading our thoughts. That's not true.
Half of men and two-thirds of women, the first symptom of heart disease is when it kills you.
This is probably the most critical time in human history. So try not to die for the next 10 years.
Smoking is associated with up to 13,000% increased risk of lung cancer.
There was a trebling in the number of people with severe allergic reactions between 1998 and 2018.
In the old days, they used to call that a fishing expedition.
This has been really one of the most valuable things I've done for my health.
What I object to most about telling people that they've got a chemical imbalance is that that is a really depressing message.
Phage just means eat. It's Greek, from the Greek to eat. So bacteriophage is just a bacteria eater.
Longevity for me is not about living forever, but to maximize my healthy lifespan.
It all had to do with adult mortality. If it's high, then you can't really spend a lot of time growing up because chances are you'll get nailed and you won't leave any descendants.
If your nicotine is tobacco derived as opposed to synthetic, you are still probably assuming risk.
There is no other scientific study that reaches something near 67% of epigenetic rejuvenation in a mammal.
Once we inject these iPSCs we can clearly see the rejuvenation of the cartilage — they start to secrete more hyaluronic acid, and we succeeded to remove the pain from these knee joints.
0.3 mL of a 200 mg per mL solution, so that is 66 mg per injection, or 120 a week.
They're literally breathing death and everyone is so normalized to it that they couldn't even see it anymore.
There's trillions of new connections every second of your day, are trying to decide, should I strengthen this one, should I weaken this one, or should I leave them the same?
Our perception of time is perhaps the most important factor in how we gauge our life.
I think of flow as the maximal expression of a complex learned skill.
The lymphatic system doesn't have that at all. On its own, it's a passive system, no pump, and it's fighting gravity all the time.
Actually delving into the literature, it's a lot more complex than what I had initially been taught.
Because the ovaries are the pacemakers of aging in the human body.
Even if the correlation were perfect, we still wouldn't conclude cause and effect from this type of data — this is what we call an ecological association.
Fadogia was shown to increase testosterone in a study from Nigeria where they gave it to rats for 5 days. As far as I can tell, it's never been tested in human beings.
Up until the 1960s, if we invested a billion we got 100 new drugs, and now we get less than one for a billion.
Aging is 80% to 90% the cause of heart disease, Alzheimer's. If we didn't get old and our bodies stayed youthful, we would not get those diseases.
Happy muscles, happy brain. Unhappy muscles, unhappy brain.
We are comprised of many regulatory resources, and if you understand how they interact and how they work, then you can steer them.
I'm not arguing that. Nobody's arguing that. What the question we're asking is how low should we push it.
If you asked me what's the theme for today, I'd say sperm matter a lot.
Fat is generally viewed as bad for many wrong reasons. It should be viewed as good. We really need fat. Without fat we become very diabetic.
It really boils down to three words: poor risk-reward.
Talking about peptides as one thing is kind of like talking about drugs as one thing.
Pain is actually your body's warning system, and if you ignore the root cause, it often comes back even stronger.
Weight loss isn't just about what you eat. It's all about the signals that you send to your body all day long.
The amount of people who live to the age of 100 while smoking is extremely small.
Nuance is king when it comes to understanding how to interpret science.
It's not just that they don't take up as much glucose, but they also just can't survive — they undergo apoptosis, which means programmed cell death.
Pain is so wonderful because it's so terrible. It keeps us alive.
Women are born with a finite number of eggs. Actually, the most eggs you'll ever have is when you're in your mom's womb.
A woman comes to me and she's having panic attacks. She has B12 deficiency. I give her injection. With the first injection, her panic is gone. And I'm like, oh my god, what else am I missing?
What if it isn't your body malfunctioning, but your immune system's actually responding the way it's designed to?
Hearing loss is a huge problem. It currently affects one and a half billion people and disables half a billion of them.
It opens up this window, a habit window where your habits become more malleable. They can change more easily.
The top 50 is like the most wanted bacteria that we would all love to have in our gut.
Isn't it interesting that the more ultra-processed foods you eat, the hungrier you get.
Collagen peptides seem to be effective for improving your skin. It's a mild effect. Don't expect anything completely transformative.
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