If you walk in your corridor and there is a drop of blood there, you can tell what was the age of the person who lost that blood with a precision of plus or minus two years.
The brain is a hybrid car. So it's running on two fuels that are complementary.
It has been clearly shown that at the molecular level some of the effects of GLP-1s are independent of obesity.
Over 4 years of treatment, there was only 1 year of telomere shortening in the vitamin D randomized group, in comparison to the placebo group that had 4 years of telomere shortening.
If you have too many ways to measure something, that is a symptom that what you're measuring is not fundamental.
I tried it on myself, because nobody else was going to do anything. I didn't have a laboratory. I just had myself.
We have no tool that allows us to directly measure biological age.
Memory is really a mental representation of the past, and by its very nature it's reconstructive.
When I see a scan on a patient, it tells me your past in one scan. And if we have an opportunity to get a second scan, then I can tell you what your future looks like.
45%, nearly half of all dementia cases worldwide can be prevented with specific modifiable factors, not genetic destiny, not bad luck.
I feel like I'm in the field now almost as if I was an infectious disease doctor practicing before and after penicillin was discovered.
The cancer cells, by definition, are refusing these orders to protect.
They're sick very little time at the end of their life, usually weeks.
To some degree, insulin resistance is a common root cause for most chronic diseases.
Women at age 52, their gas tank is empty. Perimenopause is this time where it's very erratic — the tank is over full and then it goes to empty really quickly without warning.
RNA tells you what is the function of a cell, not what is the potential.
Sometimes it's like 1% science and then 99% hype — there's almost nothing to back it up in some of these cases.
Rapamycin is our best shot on goal if we want to pick a single drug to look at in the context of biological aging in humans.
Protein restriction extends lifespan in laboratory mice, and FGF21 is required for this lifespan extension.
Every time that one engages in the compulsion related to the obsession, the obsession simply becomes stronger.
What we can see with our ancestors is that they are eating a range that is not just meat, but there's also plant foods, grasses, sedges.
The brain only has so many ways of saying ouch. And so when it's inflamed, you don't feel it.
It wasn't the science that was hard. It's what the science had to survive.
The rumination, the self-criticism, the inability to be present, these are not personality traits. They are a network malfunction.
It's the most effective longevity drug that we have today. It has been for the past 15 years.
Diabetes is a symptom. High cholesterol is a symptom. Smoking is a habit.
If we didn't produce lactate, the muscles would not be able to function.
The red light therapy market is full of bold claims and easy answers, but the actual clinical literature is incredibly nuanced.
It doesn't have to be fancy. It just has to be compliant and safe and rigorous.
Not all calories are created equal? That's not true, because a calorie is just a unit of measurement. That would be like saying not all seconds on a clock are created equal.
Green leafy vegetables plus a healthy oral microbiome are what are going to protect your heart and keep your heart healthy.
Nothing looks more beautiful in your 50s than sun protection in your 20s.
7 years of 700 cholesterol without coronary atherosclerosis. And the patient in the case report was you.
Say there's 20 papers. I'd say there's probably five to six of them that are positive and the rest of them are null.
The irritable bowel causes the irritable brain, not the other way around.
The shorter your sleep, the shorter your life. Short sleep predicts all-cause mortality.
Low omega-3 is like smoking when it comes to at least our overall life expectancy.
We already have a cure for cancer. It's early detection.
They had a 13% increase in muscle mass. People should realize how much potential they have in their brains.
People are now stacking their GLP-1 as their insulin sensitivity tool, their growth hormone, and their androgen modulation therapies as this trinity stack to get very fit, very healthy quickly.
Everybody should get an AMH test. I think it's a very important marker. If you are listening to this and you want kids one day, ask your doctor for this test.
Your cholesterol level is seven times less important than your age.
The brain holds on to cholesterol like the bank holds on to its gold in the vault.
It's like putting a 1,000 horsepower F1 engine into a golf cart—you just have the machinery, but you can't go further.
Those three genes reset the age of cells — including nerves — by about 75% and then stop. They don't go more than that, which is good. We don't want to go back to zero.
Regular acquaintance is not nearly so dramatic. The more that people spend time together getting to know each other, it reduces those market forces that give the desirable people all the advantages.
You have sympathetic activation, which is your fight or flight, your nervous system being activated. You have mitochondrial dysfunction. The challenge is anytime you try to down regulate your nervous system, it actually might make you feel like you're crashing.
If you know the name of your disease, it doesn't mean you know what's wrong with you.
No, I need my colon.
The methylation estimate is actually a better predictor of your mortality risk — far better than the plasma measure.
Eat less often... if there's one thing you can suggest to live a long life, what would it be? And my answer is eat less often.
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